1. Describe the pharmacokinetics and pharmacodynamics of Simvastatin. Describe the main therapeutic indications for Simvastatin and key contraindications, identifying any relevant considerations for Moira? (400 words) (20%)
2. Identify 2 commonly used forms of glucosamine and briefly explain how they differ. Which form and what dose will you recommend for Moira going forward? Are there any safety considerations for Moira? Justify your choice of form and dose using research and appropriate databases. (400 words) (20%)
3. Black Cohosh (Cimicifuga racemosa) is a herb widely believed to help alleviate peri-menopausal symptoms.
a)What are understood to be the mechanisms of action of Black Cohosh (Cimicifuga racemosa) and how strong is the evidence for peri-menopausal relief?
b)Evaluate the suitability of this herb for Moira as a potential alternative to HRT?
c) Briefly explain the legislation governing the sale of this herb?
Moira wants your advice regarding HRT. Briefly outline the key pros and cons for Moira with reference to research. If Moira decides to proceed with HRT, identify any relevant drug nutrient interactions to consider and whether HRT would be compatible with Black Cohosh (Cimicifuga racemosa.) (400 words) (20%)